The 2024 Annual Report of the Commission of Experts for Research and Innovation should be read against the background of this tension between multiple current crises on the one hand and long-term transformation requirements on the other. In addition to statements on how transformation-oriented research and innovation policy should be designed in this situation, the Annual Report contains, as in previous years, commentaries on current research and innovation policy as well as analyses of key topics and problem areas in the German research and innovation system.